| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Cytosolic carboxypeptidase-like protein 5 (499-549 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AGBL5 |
| Gene ID: | 60509 |
| Uniprot ID: | CBPC5_HUMAN |
| Immunogen Region: | 499-549 aa |
| Specificity: | This antibody detects endogenous levels of CBPC5 at Human/Mouse/Rat |
| Immunogen: | Synthesized peptide derived from the human CBPC5 at the amino acid range 499-549 |
| Function | Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Cleaves alpha- and gamma-linked polyglutamate tubulin side-chain, as well as the branching point glutamate. Also catalyzes the removal of alpha-linked glutamate residues from the carboxy-terminus of alpha-tubulin. Mediates deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation. |
| Protein Name | Cytosolic Carboxypeptidase-Like Protein 5 Atp/Gtp-Binding Protein-Like 5 Protein Deglutamylase Ccp5 |
| Database Links | Reactome: R-HSA-8955332 |
| Cellular Localisation | Cytoplasm Cytosol Nucleus Cytoskeleton Spindle Midbody Mainly Cytoplasmic Slight Accumulation In The Nucleus Is Observed Colocalizes With Alpha-Tubulin In The Mitotic Spindle And With Midbody Microtubules In The Intercellular Bridges Formed During Cytokinesis |
| Alternative Antibody Names | Anti-Cytosolic Carboxypeptidase-Like Protein 5 antibody Anti-Atp/Gtp-Binding Protein-Like 5 antibody Anti-Protein Deglutamylase Ccp5 antibody Anti-AGBL5 antibody Anti-CCP5 antibody |
Information sourced from Uniprot.org