Anti-ADI1 antibody (71-120 aa) (STJ98823)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human ADI1 at the amino acid range 71-120
General Information
| Short Description | Rabbit polyclonal anti-Acireductone dioxygenase-requiring-requiring (71-120 aa) for use in IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC-P 1:50-200ELISA 1:10000-20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ADI1 |
| Gene ID | 55256 |
| Uniprot ID | MTND_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human ADI1 at the amino acid range 71-120 |
| Immunogen Region | 71-120 aa |
| Specificity | The antibody detects endogenous ADI1 |
Additional Info
| Function | Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line. |
| Protein Name | Acireductone DioxygenaseAcireductone DioxygenaseFe(2+-RequiringArd'Fe-ArdAcireductone DioxygenaseNi(2+-RequiringArdNi-ArdMembrane-Type 1 Matrix Metalloproteinase Cytoplasmic Tail-Binding Protein 1Mtcbp-1Submergence-Induced Protein-Like FactorSip-L |
| Database Links | Reactome: R-HSA-1237112 |
| Cellular Localisation | CytoplasmNucleusCell MembranePeripheral Membrane ProteinCytoplasmic SideLocalizes To The Plasma Membrane When Complexed To Mmp14 |
| Alternative Antibody Names | Anti-Acireductone Dioxygenase antibodyAnti-Acireductone Dioxygenase antibodyAnti-Fe(2+-Requiring antibodyAnti-Ard' antibodyAnti-Fe-Ard antibodyAnti-Acireductone Dioxygenase antibodyAnti-Ni(2+-Requiring antibodyAnti-Ard antibodyAnti-Ni-Ard antibodyAnti-Membrane-Type 1 Matrix Metalloproteinase Cytoplasmic Tail-Binding Protein 1 antibodyAnti-Mtcbp-1 antibodyAnti-Submergence-Induced Protein-Like Factor antibodyAnti-Sip-L antibodyAnti-ADI1 antibodyAnti-MTCBP1 antibodyAnti-HMFT1638 antibody |
Information sourced from Uniprot.org