| Host: | Rabbit |
| Applications: | IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Acireductone dioxygenase-requiring-requiring (71-120 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC-P 1:50-200 ELISA 1:10000-20000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ADI1 |
| Gene ID: | 55256 |
| Uniprot ID: | MTND_HUMAN |
| Immunogen Region: | 71-120 aa |
| Specificity: | The antibody detects endogenous ADI1 |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the Internal region of human ADI1 at the amino acid range 71-120 |
| Function | Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line. |
| Protein Name | Acireductone Dioxygenase Acireductone Dioxygenase Fe(2+-Requiring Ard' Fe-Ard Acireductone Dioxygenase Ni(2+-Requiring Ard Ni-Ard Membrane-Type 1 Matrix Metalloproteinase Cytoplasmic Tail-Binding Protein 1 Mtcbp-1 Submergence-Induced Protein-Like Factor Sip-L |
| Database Links | Reactome: R-HSA-1237112 |
| Cellular Localisation | Cytoplasm Nucleus Cell Membrane Peripheral Membrane Protein Cytoplasmic Side Localizes To The Plasma Membrane When Complexed To Mmp14 |
| Alternative Antibody Names | Anti-Acireductone Dioxygenase antibody Anti-Acireductone Dioxygenase antibody Anti-Fe(2+-Requiring antibody Anti-Ard' antibody Anti-Fe-Ard antibody Anti-Acireductone Dioxygenase antibody Anti-Ni(2+-Requiring antibody Anti-Ard antibody Anti-Ni-Ard antibody Anti-Membrane-Type 1 Matrix Metalloproteinase Cytoplasmic Tail-Binding Protein 1 antibody Anti-Mtcbp-1 antibody Anti-Submergence-Induced Protein-Like Factor antibody Anti-Sip-L antibody Anti-ADI1 antibody Anti-MTCBP1 antibody Anti-HMFT1638 antibody |
Information sourced from Uniprot.org