| Host: | Rabbit |
| Applications: | ELISA/IP/WB |
| Reactivity: | Dog/Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-ADCY3 is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Biotin |
| Isotype: | IgG |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Purification: | Affinity Purified |
| Concentration: | 0.68 µg/µl |
| Dilution Range: | WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:200 IHC: 1:50-1:150 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | ADCY3 |
| Gene ID: | 109 |
| Uniprot ID: | ADCY3_HUMAN |
| Immunogen: | Synthetic peptide generated against a sequence unique to PAC3 protein. All peptides were amidated before conjugation. |
| Tissue Specificity | Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level). Expressed in brain, heart, kidney, liver, lung, pancreas islets, placenta, and skeletal muscle. Detected in testis. |
| Post Translational Modifications | Sumoylated. Sumoylation is required for targeting ot olfactory cilia. N-glycosylated. Rapidly phosphorylated after stimulation by odorants or forskolin. Phosphorylation by CaMK2 at Ser-1076 down-regulates enzyme activity. |
| Function | Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis: specifically activated by G alpha protein GNAL/G(olf) in olfactory epithelium. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet. |
| Protein Name | Adenylate Cyclase Type 3 Atp Pyrophosphate-Lyase 3 Adenylate Cyclase Type Iii Ac-Iii Adenylate Cyclase - Olfactive Type Adenylyl Cyclase 3 Ac3 |
| Database Links | Reactome: R-HSA-163359 Reactome: R-HSA-163615 Reactome: R-HSA-164378 Reactome: R-HSA-170660 Reactome: R-HSA-170670 Reactome: R-HSA-381753 Reactome: R-HSA-418555 Reactome: R-HSA-418594 Reactome: R-HSA-418597 Reactome: R-HSA-432040 Reactome: R-HSA-5610787 Reactome: R-HSA-9634597 Reactome: R-HSA-9660821 Reactome: R-HSA-9664323 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Cytoplasm Cell Projection Cilium Golgi Apparatus Also Detected In The Cytoplasm Close To Lipid Droplets |
| Alternative Antibody Names | Anti-Adenylate Cyclase Type 3 antibody Anti-Atp Pyrophosphate-Lyase 3 antibody Anti-Adenylate Cyclase Type Iii antibody Anti-Ac-Iii antibody Anti-Adenylate Cyclase - Olfactive Type antibody Anti-Adenylyl Cyclase 3 antibody Anti-Ac3 antibody Anti-ADCY3 antibody Anti-KIAA0511 antibody |
Information sourced from Uniprot.org