| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ADAMTS-like protein 4 (78-128 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ADAMTSL4 |
| Gene ID: |
54507 |
| Uniprot ID: |
ATL4_HUMAN |
| Immunogen Region: |
78-128 aa |
| Specificity: |
This antibody detects endogenous levels of ATL4 at Human/Mouse/Rat |
| Immunogen: |
Synthesized peptide derived from the human ATL4 at the amino acid range 78-128 |
| Post Translational Modifications | N-glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs. N- and C-glycosylations can also facilitate secretion. |
| Function | Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis. |
| Protein Name | Adamts-Like Protein 4Adamtsl-4Thrombospondin Repeat-Containing Protein 1 |
| Database Links | Reactome: R-HSA-5083635Reactome: R-HSA-5173214 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixColocalizes With Fmn1 Microfibrils In The Eye Ecm |
| Alternative Antibody Names | Anti-Adamts-Like Protein 4 antibodyAnti-Adamtsl-4 antibodyAnti-Thrombospondin Repeat-Containing Protein 1 antibodyAnti-ADAMTSL4 antibodyAnti-TSRC1 antibodyAnti-PP1396 antibodyAnti-UNQ2803 antibodyAnti-PRO34012 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
