| Post Translational Modifications | N-glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs. N- and C-glycosylations can also facilitate secretion. |
| Function | Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis. |
| Protein Name | Adamts-Like Protein 4Adamtsl-4Thrombospondin Repeat-Containing Protein 1 |
| Database Links | Reactome: R-HSA-5083635Reactome: R-HSA-5173214 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixColocalizes With Fmn1 Microfibrils In The Eye Ecm |
| Alternative Antibody Names | Anti-Adamts-Like Protein 4 antibodyAnti-Adamtsl-4 antibodyAnti-Thrombospondin Repeat-Containing Protein 1 antibodyAnti-ADAMTSL4 antibodyAnti-TSRC1 antibodyAnti-PP1396 antibodyAnti-UNQ2803 antibodyAnti-PRO34012 antibody |
Information sourced from Uniprot.org
