| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ADAM28 |
| Gene ID: | 10863 |
| Uniprot ID: | ADA28_HUMAN |
| Immunogen Region: | 199-440 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 199-440 of human ADAM28 (NP_055080.2). |
| Immunogen Sequence: | VQEHEKYIEYYLVLDNGEFK RYNENQDEIRKRVFEMANYV NMLYKKLNTHVALVGMEIWT DKDKIKITPNASFTLENFSK WRGSVLSRRKRHDIAQLITA TELAGTTVGLAFMSTMCSPY SVGVVQDHSDNLLRVAGTMA HEMGHNFGMFHDDYSCKCPS TICVMDKALSFYIPTDFSSC SRLSYDKFFEDKLSNCLFNA PLPTDIISTPICGNQLVEMG EDCDCGTSEECTNICCDAK |
| Tissue Specificity | Expressed predominantly in secondary lymphoid tissues, such as lymph node, spleen, small intestine, stomach, colon, appendix and trachea. The lymphocyte population is responsible for expression of this protein in these tissues. Isoform 2 is expressed preferentially in spleen. |
| Post Translational Modifications | Pro-domain removal and maturation may be, at least in part, autocatalytic. |
| Function | May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation. |
| Protein Name | Disintegrin And Metalloproteinase Domain-Containing Protein 28 Adam 28 Epididymal Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein Ii Emdc Ii Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein L Mdc-L |
| Cellular Localisation | Isoform 1: Cell Membrane Single-Pass Type I Membrane Protein Isoform 2: Secreted |
| Alternative Antibody Names | Anti-Disintegrin And Metalloproteinase Domain-Containing Protein 28 antibody Anti-Adam 28 antibody Anti-Epididymal Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein Ii antibody Anti-Emdc Ii antibody Anti-Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein L antibody Anti-Mdc-L antibody Anti-ADAM28 antibody Anti-ADAM23 antibody Anti-MDCL antibody |
Information sourced from Uniprot.org