Anti-ADAM28 antibody (199-440) (STJ117049)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ADAM28 (199-440) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ADAM28 |
| Gene ID | 10863 |
| Uniprot ID | ADA28_HUMAN |
| Immunogen Region | 199-440 |
| Immunogen Sequence | VQEHEKYIEYYLVLDNGEFK RYNENQDEIRKRVFEMANYV NMLYKKLNTHVALVGMEIWT DKDKIKITPNASFTLENFSK WRGSVLSRRKRHDIAQLITA TELAGTTVGLAFMSTMCSPY SVGVVQDHSDNLLRVAGTMA HEMGHNFGMFHDDYSCKCPS TICVMDKALSFYIPTDFSSC SRLSYDKFFEDKLSNCLFNA PLPTDIISTPICGNQLVEMG EDCDCGTSEECTNICCDAK |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 199-440 of human ADAM28 (NP_055080.2). |
Additional Info
| Tissue Specificity | Expressed predominantly in secondary lymphoid tissues, such as lymph node, spleen, small intestine, stomach, colon, appendix and trachea. The lymphocyte population is responsible for expression of this protein in these tissues. Isoform 2 is expressed preferentially in spleen. |
| Post Translational Modifications | Pro-domain removal and maturation may be, at least in part, autocatalytic. |
| Function | May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation. |
| Protein Name | Disintegrin And Metalloproteinase Domain-Containing Protein 28Adam 28Epididymal Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein IiEmdc IiMetalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein LMdc-L |
| Database Links | |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Secreted |
| Alternative Antibody Names | Anti-Disintegrin And Metalloproteinase Domain-Containing Protein 28 antibodyAnti-Adam 28 antibodyAnti-Epididymal Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein Ii antibodyAnti-Emdc Ii antibodyAnti-Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein L antibodyAnti-Mdc-L antibodyAnti-ADAM28 antibodyAnti-ADAM23 antibodyAnti-MDCL antibody |
Information sourced from Uniprot.org