Anti-ADAM22 antibody (223-400) (STJ112070)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ADAM22 (223-400) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:4000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ADAM22 |
| Gene ID | 53616 |
| Uniprot ID | ADA22_HUMAN |
| Immunogen Region | 223-400 |
| Immunogen Sequence | SKRQLRRYPRNVEEETKYIE LMIVNDHLMFKKHRLSVVHT NTYAKSVVNMADLIYKDQLK TRIVLVAMETWATDNKFAIS ENPLITLREFMKYRRDFIKE KSDAVHLFSGSQFESSRSGA AYIGGICSLLKGGGVNEFGK TDLMAVTLAQSLAHNIGIIS DKRKLASGECKCEDTWSG |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 223-400 of human ADAM22 (NP_004185.1). |
Additional Info
| Tissue Specificity | Highly expressed in the brain and in some high-grade but not low-grade gliomas. Detected slightly or not at all in other tissues. |
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. |
| Function | Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. |
| Protein Name | Disintegrin And Metalloproteinase Domain-Containing Protein 22Adam 22Metalloproteinase-Disintegrin Adam22-3Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein 2 |
| Database Links | Reactome: R-HSA-5682910 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell ProjectionAxon |
| Alternative Antibody Names | Anti-Disintegrin And Metalloproteinase Domain-Containing Protein 22 antibodyAnti-Adam 22 antibodyAnti-Metalloproteinase-Disintegrin Adam22-3 antibodyAnti-Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein 2 antibodyAnti-ADAM22 antibodyAnti-MDC2 antibody |
Information sourced from Uniprot.org