| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ADAM22 (223-400) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:4000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ADAM22 |
| Gene ID: |
53616 |
| Uniprot ID: |
ADA22_HUMAN |
| Immunogen Region: |
223-400 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 223-400 of human ADAM22 (NP_004185.1). |
| Immunogen Sequence: |
SKRQLRRYPRNVEEETKYIE LMIVNDHLMFKKHRLSVVHT NTYAKSVVNMADLIYKDQLK TRIVLVAMETWATDNKFAIS ENPLITLREFMKYRRDFIKE KSDAVHLFSGSQFESSRSGA AYIGGICSLLKGGGVNEFGK TDLMAVTLAQSLAHNIGIIS DKRKLASGECKCEDTWSG |
| Tissue Specificity | Highly expressed in the brain and in some high-grade but not low-grade gliomas. Detected slightly or not at all in other tissues. |
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. |
| Function | Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. |
| Protein Name | Disintegrin And Metalloproteinase Domain-Containing Protein 22Adam 22Metalloproteinase-Disintegrin Adam22-3Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein 2 |
| Database Links | Reactome: R-HSA-5682910 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell ProjectionAxon |
| Alternative Antibody Names | Anti-Disintegrin And Metalloproteinase Domain-Containing Protein 22 antibodyAnti-Adam 22 antibodyAnti-Metalloproteinase-Disintegrin Adam22-3 antibodyAnti-Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein 2 antibodyAnti-ADAM22 antibodyAnti-MDC2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and AK4 knockout (KO) HeLa cells, using [KO Validated] AK4 Rabbit polyclonal antibody (STJ11100730) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89668/358164/STJ11100730_1__42931.1713122467.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and AK4 knockout (KO) HeLa cells, using [KO Validated] AK4 Rabbit polyclonal antibody (STJ11100730) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")
