| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ACSS2 (462-701) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ACSS2 |
| Gene ID: |
55902 |
| Uniprot ID: |
ACSA_HUMAN |
| Immunogen Region: |
462-701 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 462-701 of human ACSS2 (NP_061147.1). |
| Immunogen Sequence: |
VDTFWQTETGGHMLTPLPGA TPMKPGSATFPFFGVAPAIL NESGEELEGEAEGYLVFKQP WPGIMRTVYGNHERFETTYF KKFPGYYVTGDGCQRDQDGY YWITGRIDDMLNVSGHLLST AEVESALVEHEAVAEAAVVG HPHPVKGECLYCFVTLCDGH TFSPKLTEELKKQIREKIGP IATPDYIQNAPGLPKTRSGK IMRRVLRKIAQNDHDLGDMS TVADPSVISHLFSHRCLTI |
| Post Translational Modifications | Reversibly acetylated at Lys-661. The acetyl-CoA synthase activity is inhibited by acetylation and activated by deacetylation mediated by the deacetylases SIRT1 and SIRT3. |
| Function | Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate. Can also utilize propionate with a much lower affinity. |
| Protein Name | Acetyl-Coenzyme A Synthetase - CytoplasmicAcetate--Coa LigaseAcetyl-Coa SynthetaseAcsAcecsAcetyl-Coa Synthetase 1Acecs1Acyl-Coa Synthetase Short-Chain Family Member 2Acyl-Activating EnzymePropionate--Coa Ligase |
| Database Links | Reactome: R-HSA-2151201Reactome: R-HSA-71384 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Acetyl-Coenzyme A Synthetase - Cytoplasmic antibodyAnti-Acetate--Coa Ligase antibodyAnti-Acetyl-Coa Synthetase antibodyAnti-Acs antibodyAnti-Acecs antibodyAnti-Acetyl-Coa Synthetase 1 antibodyAnti-Acecs1 antibodyAnti-Acyl-Coa Synthetase Short-Chain Family Member 2 antibodyAnti-Acyl-Activating Enzyme antibodyAnti-Propionate--Coa Ligase antibodyAnti-ACSS2 antibodyAnti-ACAS2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
