| Tissue Specificity | Highly expressed in liver, heart, skeletal muscle, kidney and erythroid cells, and to a lesser extent in brain, lung, placenta and pancreas. |
| Function | Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate. Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs). |
| Protein Name | Long-Chain-Fatty-Acid--Coa Ligase 1Acyl-Coa Synthetase 1Acs1Arachidonate--Coa LigaseLong-Chain Acyl-Coa Synthetase 1Lacs 1Long-Chain Acyl-Coa Synthetase 2Lacs 2Long-Chain Fatty Acid-Coa Ligase 2Palmitoyl-Coa Ligase 1Palmitoyl-Coa Ligase 2Phytanate--Coa Ligase |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-2046105Reactome: R-HSA-2046106Reactome: R-HSA-75876Reactome: R-HSA-9841922 |
| Cellular Localisation | Mitochondrion Outer MembraneSingle-Pass Type Iii Membrane ProteinPeroxisome MembraneMicrosome MembraneEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Long-Chain-Fatty-Acid--Coa Ligase 1 antibodyAnti-Acyl-Coa Synthetase 1 antibodyAnti-Acs1 antibodyAnti-Arachidonate--Coa Ligase antibodyAnti-Long-Chain Acyl-Coa Synthetase 1 antibodyAnti-Lacs 1 antibodyAnti-Long-Chain Acyl-Coa Synthetase 2 antibodyAnti-Lacs 2 antibodyAnti-Long-Chain Fatty Acid-Coa Ligase 2 antibodyAnti-Palmitoyl-Coa Ligase 1 antibodyAnti-Palmitoyl-Coa Ligase 2 antibodyAnti-Phytanate--Coa Ligase antibodyAnti-ACSL1 antibodyAnti-FACL1 antibodyAnti-FACL2 antibodyAnti-LACS antibodyAnti-LACS1 antibodyAnti-LACS2 antibody |
Information sourced from Uniprot.org
