| Function | Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Displays no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs. Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains. Moreover, it catalyzes the hydrolysis of CoA esters of bile acids, such as choloyl-CoA and chenodeoxycholoyl-CoA and competes with bile acid CoA:amino acid N-acyltransferase (BAAT). Is also able to hydrolyze CoA esters of dicarboxylic acids. It is involved in the metabolic regulation of peroxisome proliferation. (Microbial infection) May mediate Nef-induced down-regulation of CD4 cell-surface expression. |
| Protein Name | Acyl-Coenzyme A Thioesterase 8Acyl-Coa Thioesterase 8 Choloyl-Coenzyme A ThioesteraseHiv-Nef-Associated Acyl-Coa ThioesterasePeroxisomal Acyl-Coa Thioesterase 2Pte-2Peroxisomal Acyl-Coenzyme A Thioester Hydrolase 1Pte-1Peroxisomal Long-Chain Acyl-Coa Thioesterase 1Thioesterase IiHacte-IiiHacteiiiHte |
| Database Links | Reactome: R-HSA-193368Reactome: R-HSA-2046106Reactome: R-HSA-389887Reactome: R-HSA-390247Reactome: R-HSA-9033241 |
| Cellular Localisation | Peroxisome MatrixPredominantly Localized In The Peroxisome But A Localization To The Cytosol Cannot Be Excluded |
| Alternative Antibody Names | Anti-Acyl-Coenzyme A Thioesterase 8 antibodyAnti-Acyl-Coa Thioesterase 8 antibodyAnti-Choloyl-Coenzyme A Thioesterase antibodyAnti-Hiv-Nef-Associated Acyl-Coa Thioesterase antibodyAnti-Peroxisomal Acyl-Coa Thioesterase 2 antibodyAnti-Pte-2 antibodyAnti-Peroxisomal Acyl-Coenzyme A Thioester Hydrolase 1 antibodyAnti-Pte-1 antibodyAnti-Peroxisomal Long-Chain Acyl-Coa Thioesterase 1 antibodyAnti-Thioesterase Ii antibodyAnti-Hacte-Iii antibodyAnti-Hacteiii antibodyAnti-Hte antibodyAnti-ACOT8 antibodyAnti-ACTEIII antibodyAnti-PTE1 antibody |
Information sourced from Uniprot.org
