| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-ABCD2 (460-473) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:32000. WB: Approx 80kDa band observed in Human Liver lysates (calculated MW of 83.2kDa according to NP_005155.1). Recommended concentration: 0.5-2µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | ABCD2 |
| Gene ID: | 225 |
| Uniprot ID: | ABCD2_HUMAN |
| Immunogen Region: | 460-473 |
| Accession Number: | NP_005155.1 |
| Specificity: | No cross-reactivity expected with ABCD1. |
| Immunogen Sequence: | PLSDTLAIKGKVID |
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen. Like ABCD1 seems to have fatty acyl-CoA thioesterase (ACOT) and ATPase activities, according to this model, VLCFA-CoA as free VLCFA is transpoted in an ATP-dependent manner into peroxisomes after the hydrolysis of VLCFA-CoA mediated by the ACOT activity of ABCD2 (Probable). Shows overlapping substrate specificities with ABCD1 toward saturated fatty acids (FA) and monounsaturated FA (MUFA) but has a distinct substrate preference for shorter VLCFA (C22:0) and polyunsaturated fatty acid (PUFA) such as C22:6-CoA and C24:6-CoA (in vitro). Thus, may play a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation. |
| Protein Name | Atp-Binding Cassette Sub-Family D Member 2 Adrenoleukodystrophy-Like 1 Adrenoleukodystrophy-Related Protein Haldr |
| Database Links | Reactome: R-HSA-1369062 Reactome: R-HSA-9603798 |
| Cellular Localisation | Peroxisome Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family D Member 2 antibody Anti-Adrenoleukodystrophy-Like 1 antibody Anti-Adrenoleukodystrophy-Related Protein antibody Anti-Haldr antibody Anti-ABCD2 antibody Anti-ALD1 antibody Anti-ALDL1 antibody Anti-ALDR antibody Anti-ALDRP antibody |
Information sourced from Uniprot.org