Anti-ABCC6 antibody (830-940) (STJ110399)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ABCC6 (830-940) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ABCC6 |
| Gene ID | 368 |
| Uniprot ID | MRP6_HUMAN |
| Immunogen Region | 830-940 |
| Immunogen Sequence | AIAEMGSYQELLQRKGALVC LLDQARQPGDRGEGETEPGT STKDPRGTSAGRRPELRRER SIKSVPEKDRTTSEAQTEVP LDDPDRAGWPAGKDSIQYGR VKATVHLAYLR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 830-940 of human ABCC6 (NP_001162.4). |
Additional Info
| Tissue Specificity | Expressed in kidney and liver. Very low expression in other tissues. In testis, localized to peritubular myoid cells, Leydig cells, along the basal membrane of Sertoli cells and moderately in the adluminal compartment of the seminiferous tubules. |
| Post Translational Modifications | Glycosylated. |
| Function | Isoform 1: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist, BQ-123. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Does not appear to actively transport drugs outside the cell. Confers low levels of cellular resistance to etoposide, teniposide, anthracyclines and cisplatin. Isoform 1: Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis. Isoform 2: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases. |
| Protein Name | Atp-Binding Cassette Sub-Family C Member 6Anthracycline Resistance-Associated ProteinMulti-Specific Organic Anion Transporter EMoat-EMultidrug Resistance-Associated Protein 6 |
| Database Links | Reactome: R-HSA-382556Reactome: R-HSA-5690338 |
| Cellular Localisation | Basal Cell MembraneMulti-Pass Membrane ProteinLocalized To The Basal Membrane Of Sertoli CellsIsoform 1: Basolateral Cell MembraneIsoform 2: Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family C Member 6 antibodyAnti-Anthracycline Resistance-Associated Protein antibodyAnti-Multi-Specific Organic Anion Transporter E antibodyAnti-Moat-E antibodyAnti-Multidrug Resistance-Associated Protein 6 antibodyAnti-ABCC6 antibodyAnti-ARA antibodyAnti-MRP6 antibody |
Information sourced from Uniprot.org