| Host: | Goat |
| Applications: | Pep-ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-ABCB8 (C-Term) is suitable for use in ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:128000. WB: Preliminary experiments gave an approx 22kDa band in lysates of cell lines HeLa and Jurkat after 0.5µg/ml antibody staining. Please note that currently we cannot find an explanation i |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | ABCB8 |
| Gene ID: | 11194 |
| Uniprot ID: | MITOS_HUMAN |
| Immunogen Region: | C-Term |
| Accession Number: | NP_009119.2 |
| Immunogen Sequence: | KKPEGPRSHQHK |
| Function | ATP-binding subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)). Together with pore-forming subunit CCDC51/MITOK of the mitoK(ATP) channel, mediates ATP-dependent potassium currents across the mitochondrial inner membrane. An increase in ATP intracellular levels closes the channel, inhibiting K(+) transport, whereas a decrease in ATP levels enhances K(+) uptake in the mitochondrial matrix. Plays a role in mitochondrial iron transport. Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes. |
| Protein Name | Mitochondrial Potassium Channel Atp-Binding Subunit Atp-Binding Cassette Sub-Family B Member 8 - Mitochondrial Abcb8 Mitochondrial Atp-Binding Cassette 1 M-Abc1 Mitochondrial Sulfonylurea-Receptor Mitosur |
| Database Links | Reactome: R-HSA-1369007 |
| Cellular Localisation | Mitochondrion Inner Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Mitochondrial Potassium Channel Atp-Binding Subunit antibody Anti-Atp-Binding Cassette Sub-Family B Member 8 - Mitochondrial antibody Anti-Abcb8 antibody Anti-Mitochondrial Atp-Binding Cassette 1 antibody Anti-M-Abc1 antibody Anti-Mitochondrial Sulfonylurea-Receptor antibody Anti-Mitosur antibody Anti-ABCB8 antibody Anti-MABC1 antibody Anti-MITOSUR antibody |
Information sourced from Uniprot.org