Anti-ABCB8 antibody (C-Term) (STJ71642)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-ABCB8 (C-Term) is suitable for use in ELISA research applications. |
| Applications | Pep-ELISA |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Preliminary experiments gave an approx 22kDa band in lysates of cell lines HeLa and Jurkat after 0.5µg/ml antibody staining. Please note that currently we cannot find an explanation i |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | ABCB8 |
| Gene ID | 11194 |
| Uniprot ID | MITOS_HUMAN |
| Accession Number | NP_009119.2 |
| Immunogen Region | C-Term |
| Immunogen Sequence | KKPEGPRSHQHK |
Additional Info
| Function | ATP-binding subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)). Together with pore-forming subunit CCDC51/MITOK of the mitoK(ATP) channel, mediates ATP-dependent potassium currents across the mitochondrial inner membrane. An increase in ATP intracellular levels closes the channel, inhibiting K(+) transport, whereas a decrease in ATP levels enhances K(+) uptake in the mitochondrial matrix. Plays a role in mitochondrial iron transport. Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes. |
| Protein Name | Mitochondrial Potassium Channel Atp-Binding SubunitAtp-Binding Cassette Sub-Family B Member 8 - MitochondrialAbcb8Mitochondrial Atp-Binding Cassette 1M-Abc1Mitochondrial Sulfonylurea-ReceptorMitosur |
| Database Links | Reactome: R-HSA-1369007 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Mitochondrial Potassium Channel Atp-Binding Subunit antibodyAnti-Atp-Binding Cassette Sub-Family B Member 8 - Mitochondrial antibodyAnti-Abcb8 antibodyAnti-Mitochondrial Atp-Binding Cassette 1 antibodyAnti-M-Abc1 antibodyAnti-Mitochondrial Sulfonylurea-Receptor antibodyAnti-Mitosur antibodyAnti-ABCB8 antibodyAnti-MABC1 antibodyAnti-MITOSUR antibody |
Information sourced from Uniprot.org