Anti-ABCB10 antibody (670-738 aa) (STJ13100670)

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STJ13100670-100
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Host: Rabbit
Applications: IHC/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal anti-ABCB10 (670-738 aa) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Lyophilised
Purification: IgG purified
Dilution Range: IHC, WB (recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Storage Instruction: Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Gene Symbol: ABCB10
Gene ID: 23456
Uniprot ID: ABCBA_HUMAN
Immunogen Region: 670-738 aa
Specificity: Specific for ABCB10.
Immunogen: A synthetic peptide from aa region 670-738 of human ABCB10 conjugated to blue carrier protein was used as the antigen.
Function ATP-dependent transporter located in the mitochondrial inner membrane that catalyzes the export of biliverdin from the mitochondrial matrix, and plays a crucial role in hemoglobin synthesis and antioxidative stress. Participates in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX). Involved in the stabilization of the iron transporter mitoferrin-1/SLC25A37. In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria.
Protein Name Atp-Binding Cassette Sub-Family B Member 10 - Mitochondrial
Abc-Mitochondrial Erythroid Protein
Abc-Me Protein
Atp-Binding Cassette Transporter 10
Abc Transporter 10 Protein
Mitochondrial Atp-Binding Cassette 2
M-Abc2
Database Links Reactome: R-HSA-1369007
Cellular Localisation Mitochondrion Inner Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Atp-Binding Cassette Sub-Family B Member 10 - Mitochondrial antibody
Anti-Abc-Mitochondrial Erythroid Protein antibody
Anti-Abc-Me Protein antibody
Anti-Atp-Binding Cassette Transporter 10 antibody
Anti-Abc Transporter 10 Protein antibody
Anti-Mitochondrial Atp-Binding Cassette 2 antibody
Anti-M-Abc2 antibody
Anti-ABCB10 antibody

Information sourced from Uniprot.org