Anti-ABCB10 antibody (670-738 aa) (STJ13100670)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from aa region 670-738 of human ABCB10 conjugated to blue carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-ABCB10 (670-738 aa) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB (recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20ยฐC for long term storage and refrigerated at 2-8ยฐC for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | ABCB10 |
| Gene ID | 23456 |
| Uniprot ID | ABCBA_HUMAN |
| Immunogen | A synthetic peptide from aa region 670-738 of human ABCB10 conjugated to blue carrier protein was used as the antigen. |
| Immunogen Region | 670-738 aa |
| Specificity | Specific for ABCB10. |
Additional Info
| Function | ATP-dependent transporter located in the mitochondrial inner membrane that catalyzes the export of biliverdin from the mitochondrial matrix, and plays a crucial role in hemoglobin synthesis and antioxidative stress. Participates in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX). Involved in the stabilization of the iron transporter mitoferrin-1/SLC25A37. In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria. |
| Protein Name | Atp-Binding Cassette Sub-Family B Member 10 - MitochondrialAbc-Mitochondrial Erythroid ProteinAbc-Me ProteinAtp-Binding Cassette Transporter 10Abc Transporter 10 ProteinMitochondrial Atp-Binding Cassette 2M-Abc2 |
| Database Links | Reactome: R-HSA-1369007 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family B Member 10 - Mitochondrial antibodyAnti-Abc-Mitochondrial Erythroid Protein antibodyAnti-Abc-Me Protein antibodyAnti-Atp-Binding Cassette Transporter 10 antibodyAnti-Abc Transporter 10 Protein antibodyAnti-Mitochondrial Atp-Binding Cassette 2 antibodyAnti-M-Abc2 antibodyAnti-ABCB10 antibody |
Information sourced from Uniprot.org