Anti-ABCA8A antibody (690-828) (STJ11103347)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ABCA8A (690-828) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Abca8a |
| Gene ID | 217258 |
| Uniprot ID | ABC8A_MOUSE |
| Immunogen Region | 690-828 |
| Immunogen Sequence | LKCAGSSLFLKKKWGIGYHL SLQLSETCVHERITSLVKQH IPDSKLSAESEGKLSYILPL ERTNKFPDLYRDLERSPDLG IENYGVSITTLTEVFLKLEG KSSIDQSDIGMTEDVQAGGA RSPERFAEVEQLVSLLNGR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 690-828 of mouse ABCA8A (NP_694785.3). |
Additional Info
| Tissue Specificity | Expressed in lung, heart, liver, skeletal muscle and testis. Highly expressed in the liver, and is also abundant in heart and skeletal muscle. Highly expressed in heart. |
| Function | Mediates cholesterol and taurocholate efflux. Through the interaction with ABCA1 potentiates the cholesterol efflux to lipid-free APOA1, in turn regulates high-density lipoprotein cholesterol levels. |
| Protein Name | Abc-Type Organic Anion Transporter Abca8aAtp-Binding Cassette Sub-Family A Member 8a |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembranePredominantly Expressed On The Sinusoidal Plasma Membrane |
| Alternative Antibody Names | Anti-Abc-Type Organic Anion Transporter Abca8a antibodyAnti-Atp-Binding Cassette Sub-Family A Member 8a antibodyAnti-Abca8a antibody |
Information sourced from Uniprot.org