| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ABCA8A (690-828) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Abca8a |
| Gene ID: |
217258 |
| Uniprot ID: |
ABC8A_MOUSE |
| Immunogen Region: |
690-828 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 690-828 of mouse ABCA8A (NP_694785.3). |
| Immunogen Sequence: |
LKCAGSSLFLKKKWGIGYHL SLQLSETCVHERITSLVKQH IPDSKLSAESEGKLSYILPL ERTNKFPDLYRDLERSPDLG IENYGVSITTLTEVFLKLEG KSSIDQSDIGMTEDVQAGGA RSPERFAEVEQLVSLLNGR |
| Tissue Specificity | Expressed in lung, heart, liver, skeletal muscle and testis. Highly expressed in the liver, and is also abundant in heart and skeletal muscle. Highly expressed in heart. |
| Function | Mediates cholesterol and taurocholate efflux. Through the interaction with ABCA1 potentiates the cholesterol efflux to lipid-free APOA1, in turn regulates high-density lipoprotein cholesterol levels. |
| Protein Name | Abc-Type Organic Anion Transporter Abca8aAtp-Binding Cassette Sub-Family A Member 8a |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembranePredominantly Expressed On The Sinusoidal Plasma Membrane |
| Alternative Antibody Names | Anti-Abc-Type Organic Anion Transporter Abca8a antibodyAnti-Atp-Binding Cassette Sub-Family A Member 8a antibodyAnti-Abca8a antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
