Anti-AANAT antibody (1-207) (STJ113429)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal AANAT (1-207) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | AANAT |
| Gene ID | 15 |
| Uniprot ID | SNAT_HUMAN |
| Immunogen Region | 1-207 |
| Immunogen Sequence | MSTQSTHPLKPEAPRLPPGI PESPSCQRRHTLPASEFRCL TPEDAVSAFEIEREAFISVL GVCPLYLDEIRHFLTLCPEL SLGWFEEGCLVAFIIGSLWD KERLMQESLTLHRSGGHIAH LHVLAVHRAFRQQGRGPILL WRYLHHLGSQPAVRRAALMC EDALVPFYERFSFHAVGPCA ITVGSLTFMELHCSLRGHPF LRRNSGC |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-207 of human AANAT (NP_001079.1). |
Additional Info
| Tissue Specificity | Highly expressed in pineal gland and at lower levels in the retina. Weak expression in several brain regions and in the pituitary gland. |
| Post Translational Modifications | cAMP-dependent phosphorylation on both N-terminal Thr-31 and C-terminal Ser-205 regulates AANAT activity by promoting interaction with 14-3-3 proteins. |
| Function | Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin. |
| Protein Name | Serotonin N-AcetyltransferaseSerotonin AcetylaseAralkylamine N-AcetyltransferaseAa-Nat |
| Database Links | Reactome: R-HSA-209931 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Serotonin N-Acetyltransferase antibodyAnti-Serotonin Acetylase antibodyAnti-Aralkylamine N-Acetyltransferase antibodyAnti-Aa-Nat antibodyAnti-AANAT antibodyAnti-SNAT antibody |
Information sourced from Uniprot.org