| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | A2M |
| Gene ID: | 2 |
| Uniprot ID: | A2MG_HUMAN |
| Immunogen Region: | 1155-1474 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1155-1474 of human Alpha-2-Macroglobulin (Alpha-2-Macroglobulin (A2M) ) (NP_000005.2). |
| Immunogen Sequence: | ALAGNQDKRKEVLKSLNEEA VKKDNSVHWERPQKPKAPVG HFYEPQAPSAEVEMTSYVLL AYLTAQPAPTSEDLTSATNI VKWITKQQNAQGGFSSTQDT VVALHALSKYGAATFTRTGK AAQVTIQSSGTFSSKFQVDN NNRLLLQQVSLPELPGEYSM KVTGEGCVYLQTSLKYNILP EKEEFPFALGVQTLPQTCDE PKAHTSFQISLSVSYTGSRS ASNMAIVDVKMVSGFIPLK |
| Tissue Specificity | Secreted in plasma. |
| Function | Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. |
| Protein Name | Alpha-2-Macroglobulin Alpha-2-M C3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 5 |
| Database Links | Reactome: R-HSA-114608 Reactome: R-HSA-140837 Reactome: R-HSA-1474228 Reactome: R-HSA-8963896 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Alpha-2-Macroglobulin antibody Anti-Alpha-2-M antibody Anti-C3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 5 antibody Anti-A2M antibody Anti-CPAMD5 antibody Anti-FWP007 antibody |
Information sourced from Uniprot.org