| Host: | Rabbit |
| Applications: | ELISA/IP/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-5HT1B (160-260) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | FITC |
| Isotype: | IgG |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Purification: | Affinity Purified |
| Concentration: | 0.5-1.5 µg/µl |
| Dilution Range: | WB: 1:2, 500-1:5, 000 DB: 1:50, 000 ELISA: 1:50, 000 IP: 1:200 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | Htr1b |
| Gene ID: | 15551 |
| Uniprot ID: | 5HT1B_MOUSE |
| Immunogen Region: | 160-260 |
| Immunogen: | Synthetic peptide taken within amino acid region 160-260 on rat 5HT1B |
| Tissue Specificity | Predominantly expressed in striatum and Purkinje cells. |
| Post Translational Modifications | Phosphorylated. Desensitization of the receptor may be mediated by its phosphorylation. Palmitoylated. |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1B is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries. |
| Protein Name | 5-Hydroxytryptamine Receptor 1b 5-Ht-1b 5-Ht1b Serotonin Receptor 1b |
| Database Links | Reactome: R-MMU-390666 Reactome: -MMU-418594 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-5-Hydroxytryptamine Receptor 1b antibody Anti-5-Ht-1b antibody Anti-5-Ht1b antibody Anti-Serotonin Receptor 1b antibody Anti-Htr1b antibody Anti-5ht1b antibody |
Information sourced from Uniprot.org