||ELISA, IP, WB
||Human, Mouse, Rat
||FOR RESEARCH USE ONLY (RUO).
||Rabbit polyclonal antibody anti-5HT1B (160-260) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
||WB: 1:2, 500-1:5, 000DB: 1:50, 000ELISA: 1:50, 000IP: 1:200
||Store at-20°C for long term storage. Avoid freeze-thaw cycles.
||Synthetic peptide taken within amino acid region 160-260 on rat 5HT1B
| Tissue Specificity || Predominantly expressed in striatum and Purkinje cells. |
| Post Translational Modifications || Phosphorylated. Palmitoylated. |
| Function || G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries. |
| Protein Name || 5-Hydroxytryptamine Receptor 1b5-Ht-1b5-Ht1bSerotonin Receptor 1b |
| Database Links || Reactome: R-MMU-390666Reactome: R-MMU-418594 |
| Cellular Localisation || Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names || Anti-5-Hydroxytryptamine Receptor 1b antibodyAnti-5-Ht-1b antibodyAnti-5-Ht1b antibodyAnti-Serotonin Receptor 1b antibodyAnti-Htr1b antibodyAnti-5ht1b antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance