||ELISA, IP, WB
||Human, Mouse, Rat
||FOR RESEARCH USE ONLY (RUO).
||Rabbit polyclonal antibody anti-5HT1A (200-250) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
||WB: 1:2, 500-1:5, 000DB: 1:50, 000ELISA: 1:50, 000IP: 1:200
||Store at-20°C for long term storage. Avoid freeze-thaw cycles.
||Synthetic peptide corresponding to amino acids within region 200-250 on rat 5-hydroxytryptamine receptor 1A protein.
| Tissue Specificity || Detected in hypothalamus, mesencephalon, amygdala, medulla, thalamus, septum and hippocampus. |
| Function || G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli. |
| Protein Name || 5-Hydroxytryptamine Receptor 1a5-Ht-1a5-Ht1aSerotonin Receptor 1a |
| Database Links || Reactome: R-RNO-390666 |
| Cellular Localisation || Cell MembraneMulti-Pass Membrane ProteinCell ProjectionDendrite |
| Alternative Antibody Names || Anti-5-Hydroxytryptamine Receptor 1a antibodyAnti-5-Ht-1a antibodyAnti-5-Ht1a antibodyAnti-Serotonin Receptor 1a antibodyAnti-Htr1a antibodyAnti-5ht1a antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance