5HT1A Blocking Peptide for STJ500001 peptide (STJ503611)
General Information
| Short Description | 5HT1A Blocking Peptide for STJ500001 is synthetically produced from the 200-250 sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | Htr1a |
| Gene ID | 24473 |
| Uniprot ID | 5HT1A_RAT |
| Immunogen | Synthetic peptide corresponding to amino acids within region 200-250 on rat 5-hydroxytrptamine receptor 1A protein. |
| Immunogen Region | 200-250 |
| Specificity | This blocking peptide is recommended for use in combination with 5HT1A antibody, STJ500001 |
Additional Info
| Tissue Specificity | Detected in hypothalamus, mesencephalon, amygdala, medulla, thalamus, septum and hippocampus. |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Beta-arrestin family members regulate signaling by mediating both receptor desensitization and resensitization processes. |
| Peptide Name | 5-Hydroxytryptamine Receptor 1a5-Ht-1a5-Ht1aSerotonin Receptor 1a |
| Database Links | Reactome: R-RNO-390666 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionDendrite |
| Alternative Peptide Names | 5-Hydroxytryptamine Receptor 1a protein5-Ht-1a protein5-Ht1a proteinSerotonin Receptor 1a proteinHtr1a protein5ht1a protein |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about 5HT1A Blocking Peptide for STJ500001 peptide (STJ503611)
This is a blocking peptide intended for use in combination with the 5HT1A antibody STJ500001. It is used in immunodepletion or immunocompetition experiments to confirm antibody specificity.
This blocking peptide is a synthetic peptide corresponding to amino acids within the 200 to 250 region of the rat 5-hydroxytryptamine receptor 1A protein (UniProt P19327).
This blocking peptide is supplied in liquid form at 2.5 mg/ml in PBS, with the option to include up to 5% DMSO. Orders exceeding 1 mg can be supplied as lyophilized powder or reconstituted in a buffer of choice.
This product is recommended for immunodepletion and immunocompetition applications. It is intended for research use only and is not suitable for diagnostic or therapeutic purposes.
This blocking peptide should be stored at -20 degrees Celsius for long-term storage. Repeated freeze-thaw cycles should be avoided to maintain product integrity.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.