ZMPSTE24 Blocking Peptide peptide (STJ505082)

Name: ZMPSTE24 Blocking Peptide peptide (STJ505082)
SKU: STJ505082-250
Price: 260.5 GBP
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ImmunogenSynthetic peptide taken within amino acid region 215-245 on human ZMPSTE24 protein.

STJ505082-250

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Short Description	ZMPSTE24 Blocking Peptide is synthetically produced from the 215-245 sequence and is suitable for use in western blot applications.
Applications	Immunodepletion/Immunocompetition
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	0.55 µg/µl
Dilution Range	WB: DB: 1:10, 000 ELISA: 1:10, 000
Formulation	Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol	ZMPSTE24
Gene ID	10269
Uniprot ID	FACE1_HUMAN
Immunogen	Synthetic peptide taken within amino acid region 215-245 on human ZMPSTE24 protein.
Immunogen Region	215-245

Tissue Specificity	Widely expressed. High levels in kidney, prostate, testis and ovary.
Function	Transmembrane metalloprotease whose catalytic activity is critical for processing lamin A/LMNA on the inner nuclear membrane and clearing clogged translocons on the endoplasmic reticulum. Proteolytically removes the C-terminal three residues of farnesylated proteins. Plays also an antiviral role independently of its protease activity by restricting enveloped RNA and DNA viruses, including influenza A, Zika, Ebola, Sindbis, vesicular stomatitis, cowpox, and vaccinia. Mechanistically, controls IFITM antiviral pathway to hinder viruses from breaching the endosomal barrier by modulating membrane fluidity.
Peptide Name	Caax Prenyl Protease 1 Homolog Farnesylated Proteins-Converting Enzyme 1 Face-1 Prenyl Protein-Specific Endoprotease 1 Zinc Metalloproteinase Ste24 Homolog
Cellular Localisation	Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein Nucleus Inner Membrane Early Endosome Membrane Late Endosome Membrane
Alternative Peptide Names	Caax Prenyl Protease 1 Homolog protein Farnesylated Proteins-Converting Enzyme 1 protein Face-1 protein Prenyl Protein-Specific Endoprotease 1 protein Zinc Metalloproteinase Ste24 Homolog protein ZMPSTE24 protein FACE1 protein STE24 protein

Information sourced from Uniprot.org