| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
ZMPSTE24 Blocking Peptide for STJ503597 is synthetically produced from the 450-480 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Concentration: |
0.55 µg/µl |
| Dilution Range: |
WB: DB: 1:10, 000ELISA: 1:10, 000 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Zmpste24 |
| Gene ID: |
230709 |
| Uniprot ID: |
FACE1_MOUSE |
| Immunogen Region: |
450-480 |
| Specificity: |
This blocking peptide is recommended for use in combination with ZMPSTE24 antibody, STJ503597 |
| Immunogen: |
Synthetic peptide taken within amino acid region 450-480 on mouse ZMPSTE24 protein. |
| Function | Transmembrane metalloprotease whose catalytic activity is critical for processing lamin A/LMNA on the inner nuclear membrane and clearing clogged translocons on the endoplasmic reticulum. Proteolytically removes the C-terminal three residues of farnesylated proteins. Plays also an antiviral role independently of its protease activity by restricting enveloped RNA and DNA viruses. Mechanistically, controls IFITM antiviral pathway to hinder viruses from breaching the endosomal barrier by modulating membrane fluidity. |
| Peptide Name | Caax Prenyl Protease 1 HomologFarnesylated Proteins-Converting Enzyme 1Face-1Prenyl Protein-Specific Endoprotease 1Zinc Metalloproteinase Ste24 Homolog |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinNucleus Inner MembraneEarly Endosome MembraneLate Endosome Membrane |
| Alternative Peptide Names | Caax Prenyl Protease 1 Homolog proteinFarnesylated Proteins-Converting Enzyme 1 proteinFace-1 proteinPrenyl Protein-Specific Endoprotease 1 proteinZinc Metalloproteinase Ste24 Homolog proteinZmpste24 proteinFace1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
