ZDHHC9 Positive Control for STJ503570 peptide (STJ505314)
SPECIFICATIONS
General Information
| Short Description | ZDHHC9 Positive Control for STJ503570 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Applications | WB |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | WB: 1:500 |
| Formulation | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | ZDHHC9 |
| Gene ID | 51114 |
| Uniprot ID | ZDHC9_HUMAN |
| Specificity | This is positive control is recommended for use in combination with ZDHHC9 antibody STJ503570. |
Additional Info
| Tissue Specificity | Highly expressed in kidney, skeletal muscle, brain, lung and liver. Absent in thymus, spleen and leukocytes. |
| Function | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as ADRB2, GSDMD, HRAS, NRAS and CGAS. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS. May have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling. Acts as a regulator of innate immunity by catalyzing palmitoylation of CGAS, thereby promoting CGAS homodimerization and cyclic GMP-AMP synthase activity. Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD. (Microbial infection) Through a sequential action with ZDHHC20, rapidly and efficiently palmitoylates SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. |
| Peptide Name | Palmitoyltransferase Zdhhc9Zinc Finger Dhhc Domain-Containing Protein 9Dhhc-9Dhhc9Zinc Finger Protein 379Zinc Finger Protein 380 |
| Database Links | Reactome: R-HSA-9648002Reactome: R-HSA-9694548 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus Membrane |
| Alternative Peptide Names | Palmitoyltransferase Zdhhc9 proteinZinc Finger Dhhc Domain-Containing Protein 9 proteinDhhc-9 proteinDhhc9 proteinZinc Finger Protein 379 proteinZinc Finger Protein 380 proteinZDHHC9 proteinCXorf11 proteinZDHHC10 proteinZNF379 proteinZNF380 proteinCGI-89 proteinUNQ261 proteinPRO298 protein |
Information sourced from Uniprot.org