| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
YME1L1 Positive Control for STJ503568 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
YME1L1 |
| Gene ID: |
10730 |
| Uniprot ID: |
YMEL1_HUMAN |
| Specificity: |
This is positive control is recommended for use in combination with YME1L1 antibody STJ503568. |
| Tissue Specificity | High expression in cardiac and skeletal muscle mitochondria. |
| Post Translational Modifications | Proteolytically processed by mitochondrial processing peptidase (MPP) to generate the mature form. |
| Function | ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region. Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Required for normal, constitutive degradation of PRELID1. Catalyzes the degradation of OMA1 in response to membrane depolarization. Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1). |
| Peptide Name | Atp-Dependent Zinc Metalloprotease Yme1l1Atp-Dependent Metalloprotease Ftsh1Meg-4Presenilin-Associated MetalloproteasePampYme1-Like Protein 1 |
| Database Links | Reactome: R-HSA-8949664 |
| Cellular Localisation | Mitochondrion Inner MembraneMitochondrion |
| Alternative Peptide Names | Atp-Dependent Zinc Metalloprotease Yme1l1 proteinAtp-Dependent Metalloprotease Ftsh1 proteinMeg-4 proteinPresenilin-Associated Metalloprotease proteinPamp proteinYme1-Like Protein 1 proteinYME1L1 proteinFTSH1 proteinYME1L proteinUNQ1868 proteinPRO4304 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
