XTP4 Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications.
Applications
WB
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Dilution Range
WB: 1:500-1:1, 000
Formulation
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Storage Instruction
Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Among normal tissues, present only in Leydig cells. Strongly up-regulated in breast cancers and in brain cancer distant metastasis (at protein level). Up-regulated in prostate cancer cells and in the higher grades of prostate adenocarcinoma (at protein level).
Post Translational Modifications
Isoprenylation facilitates association with the plasma membrane and enhances the migratory phenotype of cells by inducing increased filopodia formation.
Function
Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process.
Peptide Name
Migration And Invasion Enhancer 1Hbv X-Transactivated Gene 4 ProteinHbv Xag-Transactivated Protein 4Protein C35
Cellular Localisation
CytoplasmCytosolCell MembraneLipid-AnchorCytoplasmic SideConcentrates At The Leading Edge Of Migrating CellsLocalizes Outside Membrane Raft Regions
Alternative Peptide Names
Migration And Invasion Enhancer 1 proteinHbv X-Transactivated Gene 4 Protein proteinHbv Xag-Transactivated Protein 4 proteinProtein C35 proteinMIEN1 proteinC17orf37 proteinRDX12 proteinXTP4 protein
