| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
VPS36 Blocking Peptide for STJ503505 is synthetically produced from the 250-310 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
VPS36 |
| Gene ID: |
51028 |
| Uniprot ID: |
VPS36_HUMAN |
| Immunogen Region: |
250-310 |
| Specificity: |
This blocking peptide is recommended for use in combination with VPS36 antibody, STJ503505 |
| Immunogen: |
Synthetic peptide taken within amino acid region 250-310 on human Vacuolar Protein-Sorting-associated protein 36 protein. |
| Function | Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3. |
| Peptide Name | Vacuolar Protein-Sorting-Associated Protein 36Ell-Associated Protein Of 45 KdaEscrt-Ii Complex Subunit Vps36 |
| Database Links | Reactome: R-HSA-917729Reactome: R-HSA-9610379 |
| Cellular Localisation | CytoplasmEndosomeLate EndosomeMembraneNucleusColocalizes With Ubiquitinated Proteins On Late EndosomesRecruited To The Endosome Membrane To Participate In Vesicle Formation |
| Alternative Peptide Names | Vacuolar Protein-Sorting-Associated Protein 36 proteinEll-Associated Protein Of 45 Kda proteinEscrt-Ii Complex Subunit Vps36 proteinVPS36 proteinC13orf9 proteinEAP45 proteinCGI-145 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
