| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Visfatin Blocking Peptide is synthetically produced from the 400-490 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Dilution Range: |
WB: IHC: 1:100 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
NAMPT |
| Gene ID: |
10135 |
| Uniprot ID: |
NAMPT_HUMAN |
| Immunogen Region: |
400-490 |
| Immunogen: |
C-epitope synthetic peptide taken within amino acid region 400-490 on human Visfatin protein |
| Tissue Specificity | Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues. |
| Function | Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression. |
| Peptide Name | Nicotinamide PhosphoribosyltransferaseNamprtaseNamptPre-B-Cell Colony-Enhancing Factor 1Pre-B Cell-Enhancing FactorVisfatin |
| Database Links | Reactome: R-HSA-1368108Reactome: R-HSA-197264Reactome: R-HSA-9768919 |
| Cellular Localisation | NucleusCytoplasmSecretedUnder Non-Inflammatory ConditionsVisfatin Predominantly Exhibits A Granular Pattern Within The NucleusSecreted By Endothelial Cells Upon Il-1beta StimulationAbundantly Secreted In MilkReaching 100-Fold Higher Concentrations Compared To Maternal Serum |
| Alternative Peptide Names | Nicotinamide Phosphoribosyltransferase proteinNamprtase proteinNampt proteinPre-B-Cell Colony-Enhancing Factor 1 proteinPre-B Cell-Enhancing Factor proteinVisfatin proteinNAMPT proteinPBEF proteinPBEF1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
