| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
VGluT1 Blocking Peptide for STJ503486 is synthetically produced from the 1-50 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Slc17a7 |
| Gene ID: |
72961 |
| Uniprot ID: |
VGLU1_MOUSE |
| Immunogen Region: |
1-50 |
| Specificity: |
This blocking peptide is recommended for use in combination with VGluT1 antibody, STJ503486 |
| Immunogen: |
Synthetic peptide taken within amino acid region 1-50 on mouse Vesicular Glutamate transporter 1 protein. |
| Tissue Specificity | Expressed in hippocampus (at protein level). Expressed in the molecular layer of the cerebellum and in retina. |
| Function | Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate. At the synaptic vesicle membrane, mainly functions as an uniporter which transports preferentially L-glutamate but also phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane. In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane that affects the proton electrochemical gradient and promotes synaptic vesicles acidification. Moreover, may function as a K(+)/H(+) antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular glutamate uptake. The vesicular K(+)/H(+) antiport activity is electroneutral. At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation. The symporter activity is driven by an inside negative membrane potential and is electrogenic. Is necessary for synaptic signaling of visual-evoked responses from photoreceptors. |
| Peptide Name | Vesicular Glutamate Transporter 1Vglut1Brain-Specific Na(+-Dependent Inorganic Phosphate CotransporterSolute Carrier Family 17 Member 7 |
| Database Links | Reactome: R-MMU-210500Reactome: -MMU-428643 |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneCell MembraneMulti-Pass Membrane ProteinSynapseSynaptosome |
| Alternative Peptide Names | Vesicular Glutamate Transporter 1 proteinVglut1 proteinBrain-Specific Na(+-Dependent Inorganic Phosphate Cotransporter proteinSolute Carrier Family 17 Member 7 proteinSlc17a7 proteinBnpi proteinVglut1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
