| Short Description : | Tyrosine Kinase Receptor C-protein was developed from hek293. For use in research applications. |
| Applications: | Block |
| Host: | HEK293 |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Purification: | Purified. The TrkC-Fc chimera consists of 15-55% carbohydrate by weight. |
| Formulation: | When reconstituted in 0.5 mL sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose. |
| Storage Instruction: | It is recommended that 0.5 mL of sterile phosphate-buffered saline be added to the vial. Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 2-8°C is recommended, and longer-term storage of aliquots at-18 |
| Gene Symbol: | NTRK3 |
| Gene ID: | 4916 |
| Uniprot ID: | NTRK3_HUMAN |
| Post Translational Modifications | Ligand-mediated auto-phosphorylation. |
| Function | Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. |
| Protein Name | Nt-3 Growth Factor ReceptorGp145-TrkcTrk-CNeurotrophic Tyrosine Kinase Receptor Type 3Trkc Tyrosine Kinase |
| Database Links | Reactome: R-HSA-1257604Reactome: R-HSA-2219530Reactome: R-HSA-388844Reactome: R-HSA-6811558Reactome: R-HSA-9034013Reactome: R-HSA-9034015Reactome: R-HSA-9034793Reactome: R-HSA-9034864Reactome: R-HSA-9603381Reactome: R-HSA-9603505 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Nt-3 Growth Factor Receptor proteinGp145-Trkc proteinTrk-C proteinNeurotrophic Tyrosine Kinase Receptor Type 3 proteinTrkc Tyrosine Kinase proteinNTRK3 proteinTRKC protein |
Information sourced from Uniprot.org
