Twist Positive Control peptide (STJ505656)

SKU:
STJ505656-5

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Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Twist Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:2, 500-1:5, 000
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: TWIST1
Gene ID: 7291
Uniprot ID: TWST1_HUMAN
Immunogen: Purified Twist protein.
Function Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-BMAL1 heterodimer.
Peptide Name Twist-Related Protein 1
Class A Basic Helix-Loop-Helix Protein 38
Bhlha38
H-Twist
Database Links Reactome: R-HSA-6785807
Reactome: R-HSA-8878166
Reactome: R-HSA-8939902
Cellular Localisation Nucleus
Alternative Peptide Names Twist-Related Protein 1 protein
Class A Basic Helix-Loop-Helix Protein 38 protein
Bhlha38 protein
H-Twist protein
TWIST1 protein
BHLHA38 protein
TWIST protein

Information sourced from Uniprot.org

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