Twist Blocking Peptide peptide (STJ505655)

Name: Twist Blocking Peptide peptide (STJ505655)
SKU: STJ505655-250
Price: 260.5 GBP
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ImmunogenSynthetic peptide take within amino acid region 50-100 on human Twist-related protein 1.

STJ505655-250

Current Stock:

🚚 Free UK Delivery on orders over £150

Quantity:

Processing The item has been added

Enquire For Bulk Order

✓ 1-Year Performance Guarantee | SDS & Datasheet Included | Expert Tech Support | Covered by St John's Laboratory Guarantee

Short Description	Twist Blocking Peptide is synthetically produced from the 50-100 sequence and is suitable for use in western blot applications.
Applications	Immunodepletion/Immunocompetition
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Formulation	Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol	TWIST1
Gene ID	7291
Uniprot ID	TWST1_HUMAN
Immunogen	Synthetic peptide take within amino acid region 50-100 on human Twist-related protein 1.
Immunogen Region	50-100

Function	Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-BMAL1 heterodimer.
Peptide Name	Twist-Related Protein 1 Class A Basic Helix-Loop-Helix Protein 38 Bhlha38 H-Twist
Database Links	Reactome: R-HSA-6785807 Reactome: R-HSA-8878166 Reactome: R-HSA-8939902 Reactome: R-HSA-9725371
Cellular Localisation	Nucleus
Alternative Peptide Names	Twist-Related Protein 1 protein Class A Basic Helix-Loop-Helix Protein 38 protein Bhlha38 protein H-Twist protein TWIST1 protein BHLHA38 protein TWIST protein

Information sourced from Uniprot.org