TRPM8 Positive Control for STJ503412 peptide (STJ505235)

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STJ505235-5

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Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: TRPM8 Positive Control for STJ503412 is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Trpm8
Gene ID: 171384
Uniprot ID: TRPM8_RAT
Specificity: This is positive control is recommended for use in combination with TRPM8 antibody STJ503412.
Tissue Specificity Expressed in dorsal root and trigeminal ganglia. Specifically expressed in a subset of sensory neurons, including cold-sensitive neurons in trigeminal neurons.
Function Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
Peptide Name Transient Receptor Potential Cation Channel Subfamily M Member 8
Cold Menthol Receptor 1
Database Links Reactome: R-RNO-3295583
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Membrane Raft
Localizes To Membrane Rafts But Is Also Located In The Cell Membrane Outside Of These Regions Where Channel Response To Cold Is Enhanced Compared To Membrane Rafts
Alternative Peptide Names Transient Receptor Potential Cation Channel Subfamily M Member 8 protein
Cold Menthol Receptor 1 protein
Trpm8 protein
Cmr1 protein

Information sourced from Uniprot.org

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