TPCN1 Blocking Peptide for STJ503363 is synthetically produced from the sequence and is suitable for use in western blot applications.
Applications
Immunodepletion/Immunocompetition
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Formulation
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction
Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Synthetic peptide taken within TMD7 and TMD8 on human TPC1 protein.
Specificity
This blocking peptide is recommended for use in combination with TPCN1 antibody, STJ503363
Additional Info
Tissue Specificity
Highest expression found in the heart and kidney, and lowest expression found in the spleen.
Post Translational Modifications
N-glycosylated.
Function
Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a voltage-gated highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) that senses pH changes and confers electrical excitability to organelles. Localizes to the early and recycling endosomes membranes where it plays a role in the uptake and processing of proteins and regulates organellar membrane excitability, membrane trafficking and pH homeostasis (Probable). Ion selectivity is not fixed but rather agonist-dependent and under defined ionic conditions, can be readily activated by both NAADP and PI(3,5)P2 (Probable). Required for mTOR-dependent nutrient sensing (Probable). (Microbial infection) During Ebola virus (EBOV) infection, controls the movement of endosomes containing virus particles and is required by EBOV to escape from the endosomal network into the cell cytoplasm.
Peptide Name
Two Pore Channel Protein 1Two Pore Calcium Channel Protein 1Voltage-Dependent Calcium Channel Protein Tpc1
Two Pore Channel Protein 1 proteinTwo Pore Calcium Channel Protein 1 proteinVoltage-Dependent Calcium Channel Protein Tpc1 proteinTPCN1 proteinKIAA1169 proteinTPC1 protein
