TMEM16A Blocking Peptide peptide (STJ505016)

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STJ505016-250

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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: TMEM16A Blocking Peptide is synthetically produced from the 900-950 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: ANO1
Gene ID: 55107
Uniprot ID: ANO1_HUMAN
Immunogen Region: 900-950
Immunogen: Synthetic peptide taken within amino acid region 900-950 on human Transmembrane protein 16A.
Tissue Specificity Expressed in nasal epithelial cells (at protein level). In the kidney, expressed in the collecting duct (at protein level). Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles. Expressed in eccrine sweat glands.
Function Calcium-activated chloride channel (CaCC). Plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Required for CFTR activation by enhancing endoplasmic reticulum Ca(2+) store release and is also required for CFTR membrane expression. Required for basal and ATP-dependent mucus secretion in airways and intestine, probably by controlling exocytosis of mucus-filled granules by providing Ca(2+) to an apical signaling compartment. Contributes to airway mucus expression induced by interleukins IL3 and IL8 and by the asthma-associated protein CLCA1 and is required for expression of mucin MUC5AC. However, was shown in another study not to be required for MUC5AC expression. Plays a role in the propagation of Ca(2+) waves in Kolliker's organ in the cochlea and contributes to the refinement of auditory brainstem circuitries prior to hearing onset. In vomeronasal sensory neurons, modulates spontaneous firing patterns in the absence of stimuli as well as the firing pattern of pheromone-evoked activity. Responsible for calcium-activated chloride channel activity in type I taste cells of the vallate papillae. Acts as a heat sensor in nociceptive neurons. In dorsal root ganglion neurons, plays a role in mediating non-histaminergic Mas-related G-protein coupled receptor (MRGPR)-dependent itching, acting as a downstream effector of MRGPRs. In the developing brain, required for the Ca(2+)-dependent process extension of radial glial cells. Isoform 4: Calcium-activated chloride channel (CaCC). Contributes to calcium-activated chloride secretion in human sweat gland epithelial cells. Shows increased basal chloride permeability and decreased Ca(2+)-induced chloride permeability. Isoform 5: Calcium-activated chloride channel (CaCC). Shows increased sensitivity to intracellular Ca(2+).
Peptide Name Anoctamin-1
Discovered On Gastrointestinal Stromal Tumors Protein 1
Oral Cancer Overexpressed Protein 2
Transmembrane Protein 16a
Tumor-Amplified And Overexpressed Sequence 2
Database Links Reactome: R-HSA-2672351
Reactome: R-HSA-9733458
Cellular Localisation Apical Cell Membrane
Multi-Pass Membrane Protein
Presynapse
In Differentiating Airway Epithelial Cells
Predominantly Intracellular At Day 0 But Is Apically Localized By Day 30
Expressed In The Presynapse Of Retinal Neurons
Alternative Peptide Names Anoctamin-1 protein
Discovered On Gastrointestinal Stromal Tumors Protein 1 protein
Oral Cancer Overexpressed Protein 2 protein
Transmembrane Protein 16a protein
Tumor-Amplified And Overexpressed Sequence 2 protein
ANO1 protein
DOG1 protein
ORAOV2 protein
TAOS2 protein
TMEM16A protein

Information sourced from Uniprot.org

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