TMC1 Blocking Peptide for STJ503319 peptide (STJ505685)
SPECIFICATIONS
ImmunogenSynthetic peptide taken within amino acid region 710-760 on human Transmembrane channel-like protein 1.
General Information
| Short Description | TMC1 Blocking Peptide for STJ503319 is synthetically produced from the 710-760 sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | TMC1 |
| Gene ID | 117531 |
| Uniprot ID | TMC1_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 710-760 on human Transmembrane channel-like protein 1. |
| Immunogen Region | 710-760 |
| Specificity | This blocking peptide is recommended for use in combination with TMC1 antibody, STJ503319 |
Additional Info
| Tissue Specificity | Detected in fetal cochlea, and at low levels in placenta and testis. |
| Function | Pore-forming subunit of the mechanotransducer (MET) non-selective cation channel complex located at the tips of stereocilia of cochlear hair cells and that mediates sensory transduction in the auditory system. The MET complex is composed of two dimeric pore-forming ion-conducting transmembrane TMC (TMC1 or TMC2) subunits, and aided by several auxiliary proteins including LHFPL5, TMIE, CIB2/3 and TOMT, and the tip-link PCDH15. MET channel is activated by tension in the tip-link extending from the side wall of one stereocilium to the tip of the adjacent shorter stereocilium, where the channel is located. TMC1 MET channel is highly permeable to calcium and likely transports monovalent cations. Also involved in vestibular hair cells transduction current. |
| Peptide Name | Transmembrane Channel-Like Protein 1Transmembrane Cochlear-Expressed Protein 1 |
| Database Links | Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinLocalized To The Stereocilia Tips Of The Cochlear Hair Cells |
| Alternative Peptide Names | Transmembrane Channel-Like Protein 1 proteinTransmembrane Cochlear-Expressed Protein 1 proteinTMC1 protein |
Information sourced from Uniprot.org