| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Themis Blocking Peptide is synthetically produced from the 1-50 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
THEMIS |
| Gene ID: |
387357 |
| Uniprot ID: |
THMS1_HUMAN |
| Immunogen Region: |
1-50 |
| Immunogen: |
Synthetic peptide taken within amino acid region 1-50 on Thymocyte-expressed molecule involved in selection protein. |
| Post Translational Modifications | Phosphorylated on Tyr residues quickly after TCR stimulation. |
| Function | Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk. |
| Peptide Name | Protein ThemisThymocyte-Expressed Molecule Involved In Selection |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Peptide Names | Protein Themis proteinThymocyte-Expressed Molecule Involved In Selection proteinTHEMIS proteinC6orf190 proteinC6orf207 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
