THAP1 Blocking Peptide for STJ503245 peptide (STJ505549)
SPECIFICATIONS
ImmunogenSynthetic peptide taken within amino acid region 150-210 on human THAP domain-containing protein 1.
General Information
| Short Description | THAP1 Blocking Peptide for STJ503245 is synthetically produced from the 150-210 sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | THAP1 |
| Gene ID | 55145 |
| Uniprot ID | THAP1_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 150-210 on human THAP domain-containing protein 1. |
| Immunogen Region | 150-210 |
| Specificity | This blocking peptide is recommended for use in combination with THAP1 antibody, STJ503245 |
Additional Info
| Tissue Specificity | Highly expressed in heart, skeletal muscle, kidney and liver. Weaker expression in brain and placenta. |
| Function | DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-ATNTNNGTGGCAAGT-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis. |
| Peptide Name | Thap Domain-Containing Protein 1 |
| Cellular Localisation | NucleusNucleoplasmPml Body |
| Alternative Peptide Names | Thap Domain-Containing Protein 1 proteinTHAP1 protein |
Information sourced from Uniprot.org