TDRKH Blocking Peptide for STJ503227 is synthetically produced from the 480-515 sequence and is suitable for use in western blot applications.
Applications
Immunodepletion/Immunocompetition
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Formulation
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction
Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Synthetic peptide taken within amino acid region 480-515 on TDRD2 protein.
Immunogen Region
480-515
Specificity
This blocking peptide is recommended for use in combination with TDRKH antibody, STJ503227
Additional Info
Post Translational Modifications
Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
Function
Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules.
Peptide Name
Tudor And Kh Domain-Containing ProteinTudor Domain-Containing Protein 2
CytoplasmMitochondrionProbable Component Of The Meiotic NuageAlso Named P GranuleA Germ-Cell-Specific Organelle Required To Repress Transposon Activity During MeiosisColocalizes With Pi- And Pip-BodiesA Subset Of The Nuage Which Contains Secondary PirnasAssociated With Mitochondria In The Germline
Alternative Peptide Names
Tudor And Kh Domain-Containing Protein proteinTudor Domain-Containing Protein 2 proteinTDRKH proteinTDRD2 protein
