| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
TDRD1 Positive Control for STJ503226 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: |
WB: 1:500 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
TDRD1 |
| Gene ID: |
56165 |
| Uniprot ID: |
TDRD1_HUMAN |
| Specificity: |
This is positive control is recommended for use in combination with TDRD1 antibody STJ503226. |
| Tissue Specificity | Testis and ovary specific. Also expressed in several cancers. |
| Function | Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins. |
| Peptide Name | Tudor Domain-Containing Protein 1Cancer/Testis Antigen 41.1Ct41.1 |
| Database Links | Reactome: R-HSA-5601884 |
| Cellular Localisation | CytoplasmComponent Of The Meiotic NuageAlso Named P GranuleA Germ-Cell-Specific Organelle Required To Repress Transposon Activity During MeiosisAlso Present In Chromatoid Body |
| Alternative Peptide Names | Tudor Domain-Containing Protein 1 proteinCancer/Testis Antigen 41.1 proteinCt41.1 proteinTDRD1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
