TDRD1 Blocking Peptide for STJ503225 peptide (STJ504984)
SPECIFICATIONS
ImmunogenSynthetic peptide taken within amino acid region 570-605 on TDRD1 protein.
General Information
| Short Description | TDRD1 Blocking Peptide for STJ503225 is synthetically produced from the 570-605 sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | TDRD1 |
| Gene ID | 56165 |
| Uniprot ID | TDRD1_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 570-605 on TDRD1 protein. |
| Immunogen Region | 570-605 |
| Specificity | This blocking peptide is recommended for use in combination with TDRD1 antibody, STJ503225 |
Additional Info
| Tissue Specificity | Testis and ovary specific. Also expressed in several cancers. |
| Function | Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins. |
| Peptide Name | Tudor Domain-Containing Protein 1Cancer/Testis Antigen 41.1Ct41.1 |
| Database Links | Reactome: R-HSA-5601884 |
| Cellular Localisation | CytoplasmComponent Of The Meiotic NuageAlso Named P GranuleA Germ-Cell-Specific Organelle Required To Repress Transposon Activity During MeiosisAlso Present In Chromatoid Body |
| Alternative Peptide Names | Tudor Domain-Containing Protein 1 proteinCancer/Testis Antigen 41.1 proteinCt41.1 proteinTDRD1 protein |
Information sourced from Uniprot.org