| Tissue Specificity | Expressed in melanocytes. |
| Post Translational Modifications | Glycosylated. |
| Function | Calcium sensor that participates in triggering neurotransmitter release at the synapse. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner.these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes. |
| Peptide Name | Synaptotagmin-1Synaptotagmin ISytiP65 |
| Database Links | Reactome: R-HSA-181429Reactome: R-HSA-181430Reactome: R-HSA-210500Reactome: R-HSA-212676Reactome: R-HSA-264642Reactome: R-HSA-5250958Reactome: R-HSA-5250989Reactome: R-HSA-6794361Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-888590 |
| Cellular Localisation | Cytoplasmic VesicleSecretory Vesicle MembraneSingle-Pass Membrane ProteinSecretory VesicleSynaptic Vesicle MembraneChromaffin Granule MembraneCytoplasm |
| Alternative Peptide Names | Synaptotagmin-1 proteinSynaptotagmin I proteinSyti proteinP65 proteinSYT1 proteinSVP65 proteinSYT protein |
Information sourced from Uniprot.org
