| Applications: | Immunodepletion/Immunocompetition |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Synaptotagmin 1 Blocking Peptide is synthetically produced from the 1-60 sequence and is suitable for use in western blot applications. |
| Formulation: | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | SYT1 |
| Gene ID: | 6857 |
| Uniprot ID: | SYT1_HUMAN |
| Immunogen Region: | 1-60 |
| Immunogen: | Synthetic peptide taken within amino acid region 1-60 on SYT1 protein. |
| Tissue Specificity | Expressed in melanocytes. |
| Post Translational Modifications | Glycosylated. |
| Function | Calcium sensor that participates in triggering neurotransmitter release at the synapse. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner.these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes. |
| Peptide Name | Synaptotagmin-1 Synaptotagmin I Syti P65 |
| Database Links | Reactome: R-HSA-181429 Reactome: R-HSA-181430 Reactome: R-HSA-210500 Reactome: R-HSA-212676 Reactome: R-HSA-264642 Reactome: R-HSA-5250958 Reactome: R-HSA-5250989 Reactome: R-HSA-6794361 Reactome: R-HSA-8856825 Reactome: R-HSA-8856828 Reactome: R-HSA-888590 |
| Cellular Localisation | Cytoplasmic Vesicle Secretory Vesicle Membrane Single-Pass Membrane Protein Secretory Vesicle Synaptic Vesicle Membrane Chromaffin Granule Membrane Cytoplasm |
| Alternative Peptide Names | Synaptotagmin-1 protein Synaptotagmin I protein Syti protein P65 protein SYT1 protein SVP65 protein SYT protein |
Information sourced from Uniprot.org