Stra6 Blocking Peptide for STJ503154 is synthetically produced from the 450-500 sequence and is suitable for use in western blot applications.
Applications
Immunodepletion/Immunocompetition
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Formulation
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction
Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Synthetic peptide taken within third large intra cytoplasmic loop within amino acid region 450-500 on human Stra6 protein.
Immunogen Region
450-500
Specificity
This blocking peptide is recommended for use in combination with Stra6 antibody, STJ503154
Additional Info
Tissue Specificity
Widely expressed in the embryo. Detected in adult in the retinal pigment epithelium in the eye. In the adult, is highly expressed in cells that compose blood-organ barriers in the brain (choroid plexus and the brain microvascular), in testis (the basal layer of the seminiferous epithelium), in the yolk sac, and in the chorioallantoic placenta. Detected in white adipose tissue and skeletal muscle, but not in liver (at protein level). Widely expressed in adult, with high expression levels in the eye. Detected in brain, cerebellum, testis, pituitary, pancreas, kidney, spleen, and female genital tract.and at very low levels in heart and lung. Not detected in liver.
Post Translational Modifications
Phosphorylated on tyrosine residues in response to RBP4 binding. Phosphorylation requires the presence of LRAT, suggesting it may be triggered by the uptake of retinol that is then metabolized within the cell to retinoids that function as signaling molecules.
Function
Functions as a retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1. Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A. Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin. Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid and 11-cis-retinal. STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency. Does not transport retinoic acid.
Peptide Name
Receptor For Retinol Uptake Stra6Retinoic Acid-Responsive ProteinRetinol-Binding Protein Receptor Stra6Stimulated By Retinoic Acid Gene 6 Protein
Cell MembraneMulti-Pass Membrane ProteinIn The Retinal Pigment Epithelium Localizes To The Basolateral MembranePlasma Membrane Of The Basal Pole Of Sertoli CellsAbsent In Plasma Membrane Of Neighboring Spermatogonia
Alternative Peptide Names
Receptor For Retinol Uptake Stra6 proteinRetinoic Acid-Responsive Protein proteinRetinol-Binding Protein Receptor Stra6 proteinStimulated By Retinoic Acid Gene 6 Protein proteinStra6 protein
